badho.blogg.se - Hydroxocobalamin cyanide antidote kit

The expert advice of a regional poison control center may be obtained by calling 1-80. Airway, ventilatory and circulatory support, and oxygen administration should not be delayed in order to administer sodium nitrite and sodium thiosulfate. Administration of sodium nitrite and sodium thiosulfate should be considered adjunctive to appropriate supportive therapies. Because of these risks, sodium thiosulfate and sodium nitrite should be used with caution in patients where the diagnosis of cyanide poisoning is uncertain.Ĭomprehensive treatment of acute cyanide intoxication requires support of vital functions. Sodium nitrite causes hypotension and methemoglobin formation, which diminishes oxygen carrying capacity. If clinical suspicion of cyanide poisoning is high, administer sodium thiosulfate and sodium nitrite without delay and in conjunction with appropriate airway, ventilatory, and circulatory support. Sodium thiosulfate 250 mg/mL injection is indicated for sequential use with sodium nitrite for treatment of acute cyanide poisoning that is judged to be serious or life-threatening. Uses for Sodium Thiosulfate (Antidote) (Systemic) Acute Cyanide Poisoning

Sodium thiosulfate is a cyanide antidote.

If needed, a second dose (half of the initial dose) may be administered.Chemical name: dioxido-oxo-sulfanylidene-lambda6-sulfane

Sodium thiosulfate should be given IV immediately following sodium nitrite administration at a dose of 12.5 g.

If needed, a second dose of up to half the previous dose may be given, as long as methemoglobin levels are kept below 35-40%. A single dose of sodium nitrite is typically enough to raise methemoglobin levels to 20% in an adult.

Once the IV line is in place, amyl nitrite should be discontinued and 10 mL of 3% sodium nitrite (300mg) should be infused IV at a rate of 2.5 - 5.0 mL/min (2-4 mins).

Reapply until sodium nitrite can be administered (IV must be in place). Amyl nitrite should be given in alternate intervals of 15 sec followed by 15 sec rest, using a new ampule every 3 minutes.

Break and ampule of amyl nitrite in a handkerchief and hold it in front of the patients mouth/nose.

1 Tourniquet & Instructions for Treatment.

12 Ampules Amyl Nitrite Inhalants (0.3 mL).

2 Vials Sodium Thiosulfate Injection (12.5 g in 50mL of water).

2 Ampules Sodium Nitrite Injection (300 mg in10mL of water).